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Established in October 2006 by Sara Zanin and originally located near the Colosseum, the gallery made its move in 2012 to a 130 square foot space in the historic center of Rome near Piazza Navona.

In 2024 z2o Sara Zanin decided to move to Testaccio, one of the most characteristic districts of Rome.

z2o Sara Zanin is interested in experimentation and research, both on individual and socio-anthropological issues, attentive to all the aspects related to the artists' practices through an annual programme of exhibitions and events. The gallery’s multidisciplinary approach focuses on the analysis of global and cultural processes, from the perspective of the artist as a privileged observer of social phenomena.

z2o Sara Zanin and the artists that it proudly represents investigate concepts such as identity, space, architecture, anthropology and nature. Therefore, z2o Sara Zanin aims to broaden its attention to talented international artists not only by sharing their works with the public, but also by sharing the works by Italian artists with a global audience, to give back a vision without geographical boundaries as well as to become an international cultural agent.

In 2020, z2o Sara Zanin opened its second venue z2o Project in San Saba (Via Baccio Pontelli 16), a research space, completely re-novated, connected with the gallery and conceived to host site-specific projects and a residency for artists.

The gallery participates in some of the most important Italian art fairs, sharing important projects with national and international institutions.